Dr. Geo Espinosa, ND, L.Ac, CNS, RH(AHG) – Naturopathic Male Health Specialist  – XY Wellness, LLC I Medical Director
When treating patients with life–threatening cellular health concerns, a reductionist approach is rarely the answer. Instead, a holistic method where multiple disease pathways are addressed offers improved clinical outcomes.
This is the case when supporting the health of oncological patients. Along with an adequate dietary regimen and prescribed physical activity, there are seven (7) botanicals I use most in my practices that has proven to be clinically effective in modulating multiple chemical pathways involved in progression of abnormal multiplying cells.
The seven carefully researched combination botanicals are:
MODIFIED CITRUS PECTIN (MCP)
Modified Citrus Pectin (MCP) holds a great deal of promise for inhibiting the spread of atypical cells by binding and blocking to galectin-3 molecules. Galectins are adhesive and blood vessel-attracting surface molecules that are thought to be involved in the spread of unwanted cells. *
GREEN TEA EXTRACT AND EGCG
Green tea and its antioxidants—polyphenols (catechins) and flavonols—account for the bulk of favorable research reports associated with overall health. Epigallocatechin gallate (EGCG) is the most powerful of these catechins. A plethora of research indicates numerous pathways where EGCG acts against undesirable aberrant cells of the prostate and of the breast.*
GANODERMA LUCIDUM (REISHI MUSHROOM)
Ganoderma lucidum, commonly known as Reishi, is a popular medicinal mushroom that has been used for centuries in Traditional Chinese Medicine (TCM) for the prevention or treatment of a variety of diseases.
A recent meta-analysis study on the use of Reishi reported immune stimulating effects with this ancient mushroom. This same report indicates a positive response in about 50 percent of patients consuming Reishi mushroom while undergoing radiation or chemotherapy, as compared to those treated with chemo or radiation alone.*
CURCUMIN
Curcumin (Curcuma longa), a member of the ginger family is found in the Indian spice, turmeric. Curcumin has been shown to exhibit powerful antioxidant activity, regulates tumor suppressor pathways and reduces chronic inflammation. Curcumin acts as a natural anti-inflammatory by suppressing major inflammatory molecules like nuclear factor- kappa beta (NF-kB), cyclooxygenase-2 (COX-2) and lipooxygenase.*
GRAPE SEED EXTRACT
Grape Seed Extract, known for its potent levels of the antioxidant proanthocyanidins, contains a broad spectrum of biological benefits including anti-oxidative, anti-inflammatory, anti-microbial and cardio-protective. One large human study found a 41% reduction in excessive cell proliferation of abnormal prostate cells only in men consuming Grape Seed Extract supplement compared to other nutrients.*
BOSWELLIA SERRATA
Boswellia serrata has several components, most notably Boswellic acid responsible for inhibiting inflammation by interfering with the production of the inflammatory biomarker 5- Lipooxygenase. However, Boswellia’s health benefits may extend beyond anti-inflammatory properties. Numerous studies reported the disruption of aberrant cell upon exposure of Boswellic acid by interfering with a process that involves the development of blood vessels that nourish such cells. *
POMEGRANATE (PUNICA GRANATUM)
The research for Pomegranate seems to indicate that the most therapeutically beneficial Pomegranate constituents are ellagic acid ellagitannins (including punicalagins), flavonoids, anthocyanidins, anthocyanins, flavonols and flavones.
Preclinical experiments provide evidence supporting that Pomegranate extracts are able to inhibit proliferation of abnormal prostate and breast growth, modulate inflammatory pathways, and reduce oxidative stress. A phase II study evaluated Pomegranate extract in 104 men with rising PSA values found that pomegranate following initial therapy for aberrant prostate stabilized PSA increase.*
Your patient is more than just the sum of his parts. Combined with targeted lifestyle changes, this botanical combination can help maximize post-diagnosis health while potentially creating an internal microenvironment that is hostile to atypical cells.


References:
Azemar M, Hildenbrand B, Haering B, Heim ME, Unger C. Clinical benefit in patients with advanced solid tumors treated with modified citrus pectin: a prospective pilot study. Clin Med Oncol. 2007; 1:73–80.
Glinskii OV, Huxley VH, Glinsky GV, et al. Mechanical entrapment is insufficient and intercellular adhesion is essential for metastatic cell arrest in distant organs. Neoplasia. 2005 May; 7(5):522-7.
Pienta KJ, Naik H, Akhtar A, et al. Inhibition of spontaneous metastasis in a rat prostate cancer model by oral administration of modified citrus pectin. J Natl Cancer Inst. 1995 Mar 1; 87(5):348-53.
Azemar M, Hildenbrand B, Haering B, Heim ME, Unger C. Clinical benefit in patients with advanced solid tumors treated with modified citrus pectin: a prospective pilot study. Clin Med Oncol. 2007; 1:73–80.
Butt MS, Sultan MT. Green tea: nature’s defense against malignancies. Crit Rev Food Sci Nutr 2009; 49(5):463-73.
Gupta S et al. Prostate cancer chemoprevention by green tea: in vitro and in vivo inhibition of testosterone-mediated induction of ornithine decarboxylase. Cancer Research 1999; 59(9):2115-20.
Hussain T et al. Green tea constituent epigallocatechin-3-gallate selectively inhibits COX-2 without affecting COX-1 expression in human prostate carcinoma cells. Intl J Cancer 2005; 113(4):660-69.
Jin X, Ruiz Beguerie J, Sze DM, Chan GC.Ganoderma lucidum (Reishi mushroom) for cancer treatment.Cochrane Database Syst Rev. 2012 Jun 13;6:CD007731.
Teiten MH, Gaascht F, Eifes S, Dicato M, Diederich M. Chemopreventive potential of curcumin in prostate cancer. Genes Nutr. 2010 Mar; 5(1):61-74.
Piantino CB, Salvadori FA, Ayres PP, et al. An evaluation of the anti-neoplastic activity of curcumin in prostate cancer cell lines. Int Braz J Urol. 2009 May-Jun; 35(3):354-60; discussion 61.
Khan N, Adhami VM, Mukhtar H. Apoptosis by dietary agents for prevention and treatment of prostate cancer. Endocr Relat; Cancer. 2010 Mar; 17(1):R39-52
Ravindran J, Prasad S, Aggarwal BB. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? AAPS J. 2009 Sep;11(3):495-510.
Cheng CY, Lin YH, Su CC. Curcumin inhibits the proliferation of human hepatocellular carcinoma J5 cells by inducing endoplasmic reticulum stress and mitochondrial dysfunction. Int J Mol Med. 2010 Nov;26(5):673-8.


*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.