Preliminary research has shown that the polyphenol resveratrol can reduce inflammation. In this 2015 study featured in the Archives of Medical Research, Iranian researchers looked at the anti-inflammatory effects of resveratrol supplementation in patients with ulcerative colitis, which is a chronic inflammatory disease.

In this study, 50 patients with mild to moderate ulcerative colitis were randomly assigned to receive either 500 mg of resveratrol daily or placebo for six weeks. Blood was collected after 12-14 hours of fasting at baseline and then again at the end of the study. Outcomes measures included serum inflammatory markers, NF-kB activity in peripheral blood mononuclear cells, and quality of life. There were no changes in these measurements in the placebo group at the end of the study. The resveratrol group, however, had significant reductions in plasma levels of TNF-a, hs-CRP, and NF-kB activity (p<0.001). In addition, clinical colitis activity index scores decreased significantly in the people taking the resveratrol compared to placebo.

While this is the first study to look at resveratrol supplementation in ulcerative colitis patients, other studies have demonstrated that resveratrol can positively impact markers of inflammation. It is becoming clear that resveratrol has anti-inflammatory activity and may be a useful therapeutic agent for a wide range of inflammatory conditions.

In addition to being available as a dietary supplement, resveratrol is found in grapes (red wine and grape juice), berries, and peanuts. One fluid ounce of red wine contains only about 90 micrograms of resveratrol, which means that dietary supplements are necessary to get a therapeutic dose.

 

Samsami-kor M, Daryani NE, Asl PR, Hekmatdoost A. Anti-Inflammatory Effects of Resveratrol in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo-controlled Pilot Study. Archives of Medical Research. 2015;46:280-285.


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