By TAP Integrative

Magnesium may have a beneficial effect on blood pressure by modulating vascular tone, increasing nitric oxide release, and supporting endothelial function. To determine the pooled effect of magnesium supplementation on blood pressure, researchers conducted a meta-analysis of randomized controlled trials. The study was published in the American Journal of Clinical Nutrition in 2017.

The meta-analysis included 11 randomized controlled trials, with a total of 543 subjects. All trials involved patients with a chronic condition, such as insulin resistance, prediabetes, type 2 diabetes, cardiovascular disease, renal disease, or cancer. Of the 11 trials, 8 used magnesium chloride, 2 used magnesium asparate hydrochloride, 1 used magnesium pidolate, and 1 used Magnosolv-Granulat. Dosages ranged from 365mg to 450mg of elemental magnesium per day. Study durations ranged from 1 to 6 months.

The pooled results showed that magnesium supplementation significantly reduced both systolic blood pressure (SBP) and diastolic blood pressure (DBP) when compared with a placebo or control. Magnesium supplementation resulted in a mean SBP reduction of 4.18mmHg and a mean DBP reduction of 2.26mmHg from baseline to trial completion.

Given that even modest decreases in blood pressure translate into meaningful risk reductions for coronary heart disease, heart failure, and stroke, the hypotensive effect of magnesium supplementation is clinically meaningful. In addition to its direct hypotensive effect, additional studies have shown that magnesium may also improve conditions related to hypertension, such as insulin resistance and prediabetes. The results of this meta-analysis support a role for magnesium in managing blood pressure in patients with insulin resistance, prediabetes, and other chronic disease.



Dibaba DT, Xun P, Song Y, Rosanoff A, Shechter M, He K. The effect of magnesium supplementation on blood pressure in individuals with insulin resistance, prediabetes, or noncommunicable chronic diseases: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2017;106(3):921-929.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.