DetoxingOur bodies detox continuously as a natural function. It’s only when our detox mechanisms become overloaded that the process becomes less efficient and symptoms may occur. Toxins may be internal or external in origin. Pollution or pesticides in our food source put undue stress on our detox organs, the kidneys and liver. Improper digestion and imbalanced gut ecology provide internal forms of toxins in the way of metabolic by-products stemming from certain bacteria which have toxic side effects, and therefore impact negatively on overall health by compromising detox pathways.

Symptoms which may be relieved by following a detox program include:
• Digestive problems
• Bad breath
• Fatigue
• Irritability
• General malaise
• Constipation
• Headaches
• Itchy skin
• Skin rashes
• Joint pain
• Weight loss resistance
• Poor concentration
The human body is constantly exposed to a wide array of toxins from our surroundings and from those produced within the body. Also known as xenobiotics, toxins created externally can vary from food-borne pollutants like pesticides, herbicides and fertilizers to environmental toxins such as secondhand cigarette smoke, car exhaust, and prescription medications. Even in the absence of harmful toxins from external sources, the human body is tasked with enormous biochemical and physiological challenges from the constant creation of internal metabolic waste products.
Unfortunately, the combined burden that our environment, diet, lifestyle and metabolic processes place upon our bodies each day can overwhelm the detoxification capacity of many individuals, leading to a wide range of dysfunctions. While the human body has developed complex enzymatic mechanisms to detoxify these substances, there are, however, individual genotypic variations in detoxifying capacity that lead to decreased detoxification efficiency and efficacy and subsequently increased risk of developing certain diseases.
Even in individuals with normal or even optimally performing detoxification pathways, exposure to exogenous toxins such as heavy metals, pesticides, industrial compounds and pollutants is associated with increased risk for several types of cancers, Parkinson’s disease, fibromyalgia, multiple chemical sensitivities and chronic fatigue syndrome.
TWO-STEP PROCESS
The first phase of the detoxification process, simply called phase I, is the primary responsibility of the cytochrome P450 family of enzymes. During Phase I, cytochrome P450 enzymes initiate reactions which help polarize the lipid-soluble molecule, the first step in making a lipid soluble compound a fully water-soluble one. The reactions involved are primarily oxidation, reduction, hydrolysis, hydration and DE halogenation.
Nutritionally, the entire vitamin B family is required as co-factors in order to facilitate these reactions. Also sulfurous compounds found in the cruciferous family of vegetables like glucosinolates can help up-regulate specific enzymes in the P450 family which greatly aid in the detoxification and metabolism of hormones, in particular estrogen.
A sluggish phase II can stall the detoxification process by inhibiting the completion of the phase I intermediate metabolism. These phase I intermediates can actually be more toxic and damaging than the original toxin/molecule. Part of insuring the best possible execution of the phase II portion of the detoxification process is to supplement those constituents that are involved in reactions during phase II. Important nutrients that support and feed these reactions include the methylators such as SAMe, folate and choline, amino acids such as glutamine, glycine and taurine for amino acid conjugation, and sulfurous compounds like MSM, N- acetyl cysteine and taurine for sulfation reactions.

Designs For Health

SUPPORT THROUGH NUTRITION
Amino-D-Tox™ from Designs For Health was designed by clinicians to biochemically upregulate phase 2 detoxification. It is free of herbals, minerals and B vitamins which would also upregulate Phase 1 detoxification. Patients who are chemically injured, who have chronic illness, and who are pathologic detoxifiers (blocked Phase 2 pathway), will find that this product will gently upregulate all the conjugation pathways resulting in excretion of the pollutants without mobilizing more oxidized pollutants in the body from body fat stores.
In conclusion, it may be that the optimization of both phase I and phase II detoxifications pathways is key to a successful and less stressful detoxification process, thus helping to reduce or eliminate the chances of unfortunate side effects, which can only be achieved by ensuring proper nutritional support.


*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
**This blog was written by an outside source. This blog does not necessarily reflect the views or positions of Natural Partners.

Written By Dr. Michael Furman, Designs For Health


Helpful related links:
Designs for Health offers three unique group detox/cleanse programs that are comprehensive in their scope and very easy to implement. Learn more about each in the program brochures linked below:
14 Day Detox/Cleanse
http://www.designsforhealth.com/flyers/14day-DetoxBooklet-Rev8.16.12org.pdf
21 Day Detox/Cleanse
http://www.designsforhealth.com/flyers/21Day-DetoxTrifold-Rev10.27.11.pdf
28 Day Detox/Cleanse
http://www.designsforhealth.com/flyers/28Day-DetoxTrifold-Rev10.27.11.pdf